Transcription factors that synergize with changes in chromatin accessibility

The Brady Lab is interested in identifying and characterizing novel transcription factors that contribute to the process of lineage plasticity. We utilize a number of genetically-engineered mouse models (GEMMs), human prostate cancer cell lines, and NEPC patient-derived organoids and perform transcriptomic, cistromic, and epigenomic analysis at the bulk and single-cell level using next-generation sequencing technologies.